Universität zu Köln, Institut für Anorganische Chemie, Greinstrasse 6, D-50969, Köln, Germany.
Dalton Trans. 2010 May 14;39(18):4331-40. doi: 10.1039/b926233d. Epub 2010 Mar 25.
New organometallic palladium complexes of the general type (RR'dppz)Pd(Me)L (RR'dppz = derivatives of dipyrido[3,2-a:2',3'-c]phenazine with RR' = 11-Cl, 11,12-Cl(2), 11-CF(3), 11-NO(2), 11-NH(2); L = Cl, 1-methyluracilate (n = 0), pyridine, cytosine, caffeine, or 1-methylcytosine, (all n = 1) were characterised and studied in detail by electrochemical and spectroscopic (NMR, UV/Vis- absorption and emission) methods. EPR spectroscopy and density functional calculations reveal markedly tuneable lowest unoccupied molecular orbitals (LUMO) located at the dppz ligands. Cytotoxicity experiments on HT-29 colon carcinoma and MCF-7 breast cancer cell lines show promising activities for selected compounds.
新型有机金属钯配合物的一般类型 (RR'dppz)Pd(Me)L (RR'dppz = 二吡啶并[3,2-a:2',3'-c]吩嗪的衍生物，RR' = 11-Cl、11,12-Cl(2)、11-CF(3)、11-NO(2)、11-NH(2); L = Cl、1-甲基尿嘧啶(n = 0)、吡啶、胞嘧啶、咖啡因或 1-甲基胞嘧啶，(均 n = 1)，通过电化学和光谱学方法 (NMR、UV/Vis-吸收和发射) 进行了详细的表征和研究。电子顺磁共振波谱和密度泛函计算揭示了位于 dppz 配体上的可显著调节的最低未占据分子轨道 (LUMO)。对 HT-29 结肠癌细胞系和 MCF-7 乳腺癌细胞系的细胞毒性实验表明，所选化合物具有有希望的活性。
