State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
Dalton Trans. 2010 May 14;39(18):4435-9. doi: 10.1039/b925779a. Epub 2010 Mar 24.
We report room-temperature preparation of poly(ethylene glycol)-block-polylactide (PEG-PLA)/calcium phosphate (CP) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug, ibuprofen, is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA/CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA/CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA/CP nanocomposite is promising for application in drug delivery.
我们报道了一种在室温下制备具有多孔形貌的聚乙二醇-嵌段-聚乳酸（PEG-PLA）/磷酸钙（CP）纳米复合材料的方法。无机成分的反应时间和浓度对纳米复合材料的形态和化学成分起着重要作用。热重分析表明，纳米复合材料中约有 8.5wt%的 PEG-PLA 嵌段共聚物。我们使用一种典型的抗炎药物布洛芬来评估多孔 PEG-PLA/CP 纳米复合材料的药物负载能力和释放行为。实验表明，该纳米复合材料具有较高的药物负载能力和良好的药物释放性能。多孔 PEG-PLA/CP 纳米复合材料的药物释放动力学被讨论为一个三阶段过程。所制备的多孔 PEG-PLA/CP 纳米复合材料有望在药物输送中得到应用。
