Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
J Org Chem. 2010 May 21;75(10):3495-8. doi: 10.1021/jo100408p.
A rapid, four-step approach to alkyl- and aryl-substituted benzomorpholines is accomplished by a Pd-catalyzed domino C-C/C-N bond coupling using a norbornene template. Extension to phenoxazines and dihydrodibenzoxazepines is presented.
通过钯催化的利用降冰片烯模板的串联 C-C/C-N 键偶联反应，实现了快速的四步烷基和芳基取代苯并吗啡啉合成方法。同时还介绍了对苯并恶嗪和二氢二苯并恶嗪的扩展应用。
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