钯催化的邻乙炔基苯胺的高度区域选择性6-外向-双环环化和烯基化反应：多烯取代苯并[d][1,3]恶嗪的合成
Palladium-catalyzed highly regioselective 6-exo-dig cyclization and alkenylation of ortho-ethynylanilides: the synthesis of polyene-substituted benzo[d][1,3]oxazines.
作者信息
Cai Zhong-Jian, Yang Chao, Wang Shun-Yi, Ji Shun-Jun
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, People's Republic of China.
出版信息
Chem Commun (Camb). 2015 Sep 28;51(75):14267-70. doi: 10.1039/c5cc06510k. Epub 2015 Aug 26.
A Pd-catalyzed highly regioselective 6-exo-dig cyclization/alkenylation reaction of ortho-ethynylanilides has been developed. This tandem cross-coupling protocol represents a simple, efficient, step- and atom-economic approach for the construction of scarcely known polyene-substituted benzo[d][1,3]oxazines in moderate to excellent yields with a broad substrate scope.
已开发出一种钯催化的邻乙炔基苯胺的高度区域选择性6-外向-双环环化/烯基化反应。这种串联交叉偶联方案是一种简单、高效、步骤和原子经济的方法，用于构建鲜为人知的多烯取代苯并[d][1,3]恶嗪，产率适中至优异，底物范围广泛。
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