Fu Rui-bin, Wu Ping-sheng, Wu Shu-lin, Qiu Jian
Department of Cardiology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):771-3.
To investigate the changes of endothelial function indices and their relation to platelet activation in patients with idiopathic atrial fibrillation (AF).
We studied 61 patients with idiopathic AF with 34 age- and sex-matched healthy persons as control. Platelet counts in the blood were tested, and plasma levels of NOx were analyzed using Griess method. The plasma levels of von Willibrand factor (vWF) and soluble P-selectin (sP-selectin) were determined using enzyme-linked immunosorbent assay.
Compared to healthy control, the patients with idiopathic AF had significantly lower levels of plasma NOx (18.2-/+7.3 vs 24.3-/+7.8 micromol/L, P=0.049) and higher levels of plasma sP-selectin (25.6-/+6.2 vs 22.4-/+4.8 ng/ml, P=0.007). No significant differences were found in the platelet counts or plasma vWF levels between the two groups. A significant inverse correlation was found between plasma NOx and sP-selectin (r=-0.405, P=0.025) in patients with idiopathic AF.
AF per se may impair the endothelial function and activate platelet function, suggesting the role of endothelial dysfunction in activated platelet function in AF patients.
探讨特发性心房颤动（AF）患者内皮功能指标的变化及其与血小板活化的关系。
我们研究了61例特发性AF患者，并以34例年龄和性别匹配的健康人作为对照。检测血液中的血小板计数，并采用格里斯法分析血浆中氮氧化物（NOx）的水平。采用酶联免疫吸附测定法测定血管性血友病因子（vWF）和可溶性P-选择素（sP-选择素）的血浆水平。
与健康对照组相比，特发性AF患者的血浆NOx水平显著降低（18.2±7.3 vs 24.3±7.8 μmol/L，P=0.049），血浆sP-选择素水平显著升高（25.6±6.2 vs 22.4±4.8 ng/ml，P=0.007）。两组之间的血小板计数或血浆vWF水平无显著差异。特发性AF患者血浆NOx与sP-选择素之间存在显著的负相关（r=-0.405，P=0.025）。
AF本身可能损害内皮功能并激活血小板功能，提示内皮功能障碍在AF患者活化血小板功能中的作用。
