University of Vienna, Department of Analytical Chemistry, Währingerstrasse 38, 1090 Vienna, Austria.
Chem Commun (Camb). 2010 May 14;46(18):3128-30. doi: 10.1039/c000936a. Epub 2010 Apr 9.
Biological information such as recognition abilities of antibodies can be transferred to man-made systems by imprinting. For instance, sensor layers with insulin-selective cavities yield similar selectivity and sensitivity as IgG. True "artificial antibodies" are achieved by synthesizing "polymer copies" retaining the original binding properties of anti-insulin IgG via two-step imprinting.
生物信息，如抗体的识别能力，可以通过印迹技术转移到人为的系统中。例如，具有胰岛素选择性空腔的传感器层可以产生与 IgG 相似的选择性和灵敏度。通过两步印迹，通过合成“保留抗胰岛素 IgG 原始结合特性的聚合物副本”，可以获得真正的“人工抗体”。
