Wu Bechien U, Conwell Darwin L
Center for Pancreatic Disease, Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Curr Gastroenterol Rep. 2010 Apr;12(2):83-90. doi: 10.1007/s11894-010-0091-6.
Acute pancreatitis is a common cause for hospitalization that carries a substantial burden of disease in the United States and worldwide. Recent reports have encompassed a wide array of topics including new insights into the acinar cell pH microenvironment, signal pathways for acinar cell fate, and the innate immune response. Clinical researchers have reported new methods to assess disease severity, innovative techniques for management of local complications, the importance of early recognition of pancreatic or extrapancreatic infection, and prevention of disease recurrence. Recent data also suggest that specialized centers may be of benefit for the management of severe acute pancreatitis. This review summarizes a number of recent advances in basic and clinical science with an emphasis on findings that are relevant to clinicians who manage patients with acute pancreatitis.
急性胰腺炎是住院治疗的常见病因，在美国乃至全球都造成了沉重的疾病负担。最近的报告涵盖了广泛的主题，包括对腺泡细胞pH微环境的新见解、腺泡细胞命运的信号通路以及先天性免疫反应。临床研究人员报告了评估疾病严重程度的新方法、处理局部并发症的创新技术、早期识别胰腺或胰腺外感染的重要性以及预防疾病复发。最新数据还表明，专业中心可能有助于管理重症急性胰腺炎。本综述总结了基础和临床科学方面的一些最新进展，重点是与管理急性胰腺炎患者的临床医生相关的研究结果。
