College of Sciences, Northeastern University, Shenyang 110004, China.
Langmuir. 2010 Jun 1;26(11):8270-3. doi: 10.1021/la101123y.
Layer-by-layer (LBL) films of poly(lactic acid) nanoparticles (PLA NPs) and poly(ethyleneimine) (PEI) were fabricated as a novel drug-delivery system. The PLA NPs, which encapsulated pyrene as a model drug, were prepared by nanoprecipitation methods. The assembly process of PLA NPs/PEI LBL films was monitored by UV-vis spectroscopy, and the load of pyrene in the multilayer films was verified by fluorescence spectroscopy. The morphology of the PLA NPs/PEI LBL films was observed by SEM. The release profile of pyrene from the LBL films in PBS solutions was further studied, and the result indicated that the PLA NPs/PEI films were capable of sustainably releasing pyrene as expected. The fabrication of PLA NPs/PEI LBL films provides a new facile method for drug delivery and paves the way for loading multiple types of drugs into a single LBL film.
层层（LBL）聚乳酸纳米粒子（PLA NPs）和聚乙烯亚胺（PEI）薄膜被制备为一种新型药物传递系统。PLA NPs 通过纳米沉淀法制备，包封了芘作为模型药物。通过紫外-可见光谱监测 PLA NPs/PEI LBL 薄膜的组装过程，并通过荧光光谱验证多层薄膜中芘的负载量。通过 SEM 观察 PLA NPs/PEI LBL 薄膜的形态。进一步研究了 LBL 薄膜在 PBS 溶液中芘的释放情况，结果表明 PLA NPs/PEI 薄膜能够如预期的那样持续释放芘。PLA NPs/PEI LBL 薄膜的制备为药物传递提供了一种新的简便方法，并为将多种类型的药物装入单个 LBL 薄膜铺平了道路。
