[自身免疫性溶血性贫血伴严重巨细胞性肝炎]

[Autoimmune hemolytic anemia associated with severe giant cell hepatitis].

作者信息

Camarero Salcés C, Vasconez Muñoz F, San José Hernando D, Morales P, Suárez Cortina L, Parra Vázquez C, Escobar Castro H, Muñoz Villa A

机构信息

Servicio de Pediatría, Hospital Ramón y Cajal, Madrid.

出版信息

An Esp Pediatr. 1991 Feb;34(2):149-51.

PMID:2042809

Abstract

Autoimmune hemolytic anemia and severe giant cell hepatitis is an very uncommon association. Two patients aged 5 months and 2 years developed severe anemia, jaundice, hepatomegaly and splenomegaly. Laboratory tests demonstrated autoimmune hemolytic anemia and elevated amino-transferases. Diffuse giant cell transformation and distorted architecture was seen in liver biopsy. One patient had a cytomegalovirus infection. Early steroid therapy did not prevent fatal course with liver failure in one patient.

摘要

自身免疫性溶血性贫血与严重巨细胞性肝炎是一种非常罕见的关联。两名年龄分别为5个月和2岁的患儿出现了严重贫血、黄疸、肝肿大和脾肿大。实验室检查显示为自身免疫性溶血性贫血以及转氨酶升高。肝活检可见弥漫性巨细胞转化和结构扭曲。其中一名患儿感染了巨细胞病毒。早期使用类固醇治疗未能阻止一名患儿因肝衰竭而出现致命病程。