范可尼贫血症与乳腺癌易感性再次相遇。
Fanconi anemia and breast cancer susceptibility meet again.
机构信息
Medical Genetics Institute, Shaare Zedek Medical Center (Hebrew University), Jerusalem, Israel.
出版信息
Nat Genet. 2010 May;42(5):368-9. doi: 10.1038/ng0510-368.
PMID:20428093
Abstract
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer-associated pathways.
摘要
一项新的研究报告称，在类范可尼贫血症中发现 RAD51C 的双等位基因突变，而第二项研究则报告称，同一基因的单等位基因突变与乳腺癌风险增加相关。这些发现加强了范可尼贫血症和乳腺癌相关途径之间的联系。
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