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Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.人类RAD52——癌症与免疫缺陷中DNA修复的新角色。
Haematologica. 2017 Feb;102(2):e69-e72. doi: 10.3324/haematol.2016.155838. Epub 2016 Dec 15.
2
Identification of a second DNA binding site in the human Rad52 protein.人类Rad52蛋白中第二个DNA结合位点的鉴定。
J Biol Chem. 2008 Aug 29;283(35):24264-73. doi: 10.1074/jbc.M802204200. Epub 2008 Jul 1.
3
Rad52.Rad52。
Curr Biol. 2009 Aug 25;19(16):R676-7. doi: 10.1016/j.cub.2009.06.001.
4
Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair.Rad52反向链交换驱动RNA模板化的DNA双链断裂修复。
Mol Cell. 2017 Jul 6;67(1):19-29.e3. doi: 10.1016/j.molcel.2017.05.019. Epub 2017 Jun 8.
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Rad52, Maestro of Inverse Strand Exchange.Rad52,反向链交换的大师。
Mol Cell. 2017 Jul 6;67(1):1-3. doi: 10.1016/j.molcel.2017.06.015.
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Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.缺乏RAD52的人类体细胞在病毒整合方面受损,并且在同源定向修复的大多数方面都存在缺陷。
DNA Repair (Amst). 2017 Jul;55:64-75. doi: 10.1016/j.dnarep.2017.04.006. Epub 2017 May 10.
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Rad52 and Rad59 exhibit both overlapping and distinct functions.Rad52和Rad59表现出重叠和不同的功能。
DNA Repair (Amst). 2007 Jan 4;6(1):27-37. doi: 10.1016/j.dnarep.2006.08.007. Epub 2006 Sep 20.
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Multiple start codons and phosphorylation result in discrete Rad52 protein species.多个起始密码子和磷酸化作用导致形成不同的Rad52蛋白种类。
Nucleic Acids Res. 2006 May 17;34(9):2587-97. doi: 10.1093/nar/gkl280. Print 2006.
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MTE1 Functions with MPH1 in Double-Strand Break Repair.MTE1在双链断裂修复中与MPH1共同发挥作用。
Genetics. 2016 May;203(1):147-57. doi: 10.1534/genetics.115.185454. Epub 2016 Feb 26.
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Increased age-adjusted hazard of death associated with a common single nucleotide polymorphism of the human RAD52 gene in a cardiovascular cohort.在心血管队列中,人类 RAD52 基因的常见单核苷酸多态性与年龄调整后死亡风险增加相关。
Mech Ageing Dev. 2017 Oct;167:56-63. doi: 10.1016/j.mad.2017.10.003. Epub 2017 Oct 9.

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Expression-Based Diagnosis, Treatment Selection, and Drug Development for Breast Cancer.基于表达谱的乳腺癌诊断、治疗选择和药物研发。
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Influence of the detection of parent-of-origin on the pregnancy outcomes of fetuses with copy number variation of unknown significance.父源检测对意义不明拷贝数变异胎儿妊娠结局的影响。
Sci Rep. 2020 Jun 1;10(1):8864. doi: 10.1038/s41598-020-65904-2.
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Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.遗传性癌症儿童-受影响家庭对 Trio-WES 的接受程度。
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本文引用的文献

1
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.一种与RAD51显性负性突变相关的新型范可尼贫血亚型。
Nat Commun. 2015 Dec 18;6:8829. doi: 10.1038/ncomms9829.
2
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.酿酒酵母Rad51旁系同源蛋白与Rad52共同促进突触前细丝组装。
Nat Commun. 2015 Jul 28;6:7834. doi: 10.1038/ncomms8834.
3
Stress and DNA repair biology of the Fanconi anemia pathway.范可尼贫血途径的应激和 DNA 修复生物学。
Blood. 2014 Oct 30;124(18):2812-9. doi: 10.1182/blood-2014-04-526293. Epub 2014 Sep 18.
4
The clinical impact of deficiency in DNA non-homologous end-joining.DNA非同源末端连接缺陷的临床影响。
DNA Repair (Amst). 2014 Apr;16:84-96. doi: 10.1016/j.dnarep.2014.02.011. Epub 2014 Mar 11.
5
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.分子途径:了解 Rad52 在同源重组中的作用,以推进治疗进展。
Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15.
6
RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination.RAD52 失活与 BRCA1 和 PALB2 缺陷以及 BRCA2 缺陷一样,通过 RAD51 介导的同源重组导致合成致死。
Oncogene. 2013 Jul 25;32(30):3552-8. doi: 10.1038/onc.2012.391. Epub 2012 Sep 10.
7
Rad52 inactivation is synthetically lethal with BRCA2 deficiency.Rad52 失活与 BRCA2 缺陷具有合成致死性。
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):686-91. doi: 10.1073/pnas.1010959107. Epub 2010 Dec 8.
8
Fanconi anemia and breast cancer susceptibility meet again.范可尼贫血症与乳腺癌易感性再次相遇。
Nat Genet. 2010 May;42(5):368-9. doi: 10.1038/ng0510-368.
9
DNA interstrand crosslink repair in mammalian cells: step by step.哺乳动物细胞中的 DNA 链间交联修复:步步为营。
Crit Rev Biochem Mol Biol. 2010 Feb;45(1):23-49. doi: 10.3109/10409230903501819.
10
Identification of a second DNA binding site in the human Rad52 protein.人类Rad52蛋白中第二个DNA结合位点的鉴定。
J Biol Chem. 2008 Aug 29;283(35):24264-73. doi: 10.1074/jbc.M802204200. Epub 2008 Jul 1.

Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.

作者信息

Ghosh Sujal, Hönscheid Andrea, Dückers Gregor, Ginzel Sebastian, Gohlke Holger, Gombert Michael, Kempkes Bettina, Klapper Wolfram, Kuhlen Michaela, Laws Hans-Jürgen, Linka René Martin, Meisel Roland, Mielke Christian, Niehues Tim, Schindler Detlev, Schneider Dominik, Schuster Friedhelm R, Speckmann Carsten, Borkhardt Arndt

机构信息

Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Center of Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany

Infection, Immunity, Inflammation, Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

出版信息

Haematologica. 2017 Feb;102(2):e69-e72. doi: 10.3324/haematol.2016.155838. Epub 2016 Dec 15.

DOI:10.3324/haematol.2016.155838
PMID:27979922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5286958/
Abstract
摘要