Department of Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Mem Inst Oswaldo Cruz. 2010 Mar;105(2):149-54. doi: 10.1590/s0074-02762010000200007.
In this study, we looked at the inheritance of susceptibility and resistance to Schistosoma mansoni infection in the first generation of crossbred Biomphalaria alexandrina snails. Our ultimate goal is to use such information to develop a biological method of controlling schistosomiasis. We infected laboratory-bred snails with S. mansoni miracidia and examined cercarial shedding to determine susceptibility and resistance. Five parental groups were used: Group I contained 30 susceptible snails, Group II contained 30 resistant snails, Group III contained 15 susceptible and 15 resistant snails, Group IV contained 27 susceptible and three resistant snails and Group V contained three susceptible and 27 resistant snails. The percentage of resistant snails in the resulting progeny varied according to the ratio of susceptible and resistant parents per group; they are 7%, 100%, 68%, 45% and 97% from Groups I, II, III, IV and V, respectively. On increasing the percentage of resistant parent snails, the percentage of resistant progeny increased, while cercarial production in their susceptible progeny decreased.
在这项研究中，我们观察了第一代杂交 B. alexandrina 蜗牛对曼氏血吸虫感染易感性和抗性的遗传。我们的最终目标是利用这些信息开发一种控制血吸虫病的生物学方法。我们用 S. mansoni 尾蚴感染实验室培育的蜗牛，并检查尾蚴脱落以确定易感性和抗性。使用了五个亲本群体：第 I 组包含 30 只易感蜗牛，第 II 组包含 30 只抗性蜗牛，第 III 组包含 15 只易感和 15 只抗性蜗牛，第 IV 组包含 27 只易感和 3 只抗性蜗牛，第 V 组包含 3 只易感和 27 只抗性蜗牛。子代中抗性蜗牛的百分比根据每组易感和抗性亲本的比例而有所不同；它们分别来自 I、II、III、IV 和 V 组的 7%、100%、68%、45%和 97%。随着抗性亲本蜗牛比例的增加，抗性后代的比例增加，而其易感后代的尾蚴产量减少。
