Zakharov D G, Kuznetsov A S, Nekorkin V I
Biofizika. 2010 Mar-Apr;55(2):284-91.
A two-compartment model of the dopaminergic neuron based on modified FitzHue-Nagumo oscillators for each compartment has been built. The compartments corresponded to the soma and dendrites and differed by the values of small parameters. The influence of stimuli (applied current for the somatic compartment and synaptic activation for the dendritic compartment) on the model has been studied. It has been shown that the activation of AMPA and NMDA synaptic currents lead to the generation of high-frequency bursts by the neuron. The mechanisms underlying the generation of the bursts have been investigated.
基于对每个隔室的修正FitzHue-Nagumo振荡器构建了多巴胺能神经元的双隔室模型。这些隔室分别对应于胞体和树突，且小参数值不同。研究了刺激（胞体隔室施加电流，树突隔室突触激活）对该模型的影响。结果表明，AMPA和NMDA突触电流的激活会导致神经元产生高频爆发。对爆发产生的潜在机制进行了研究。
