Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Org Lett. 2010 May 21;12(10):2258-61. doi: 10.1021/ol100610v.
Facile and efficient Rh(I)-catalyzed domino conjugate addition-cyclization reactions of olefins bearing two electrophilic sites and a pendant nucleophile with organoboroxines have been developed to afford a variety of N- and O-heterocycles, such as 3,4-dihydroquinolin-2(1H)-ones, 3,4-dihydrocoumarins, and pyrrolidin-2-ones, which constitute important motifs in biologically active natural and synthetic organic compounds.
已开发出一种简便高效的 Rh(I)-催化的烯烃的多组分共轭加成-环化反应,该烯烃具有两个亲电位点和一个连位亲核试剂,与有机硼氧烷反应,可得到各种 N-和 O-杂环,如 3,4-二氢喹啉-2(1H)-酮、3,4-二氢香豆素和吡咯烷-2-酮,这些杂环是生物活性天然和合成有机化合物中的重要结构单元。