Medical School, Department of General Practice, University of Tampere, Finland.
Scand J Prim Health Care. 2010 Jun;28(2):102-7. doi: 10.3109/02813431003784001.
Pregnant women complaining of itching are screened for intrahepatic cholestasis (ICP) by laboratory tests in primary healthcare. Cases of ICP are referred to specialist care. In Finland, ICP occurs in 1% of pregnancies. The aim was to study the outcome of deliveries. Design. Retrospective study of ICP pregnancies. Data were collected from the hospital discharge register, patient records, and the labour register.
The region of Tampere University Hospital in Finland.
Altogether 687 ICP cases from 1969 to 1988 and two controls for each. Main outcome measures. ICP patients were compared with controls in terms of mother's age, pregnancy multiplicity, weeks of gestation at delivery, frequency of induction and Caesarean section, length of ward period, child's weight, Apgar scores, and stillbirth.
For ICP patients, the risk for hospital stay of 10 days or more was eightfold (OR 8.41), for gestational weeks less than 37 at delivery sevenfold (OR 7.02), for induction threefold (OR 3.26), for baby's low weight at birth almost twofold (OR 1.86), and for Caesarean section one and a half fold (OR 1.47). The possibility of the incidence of multiple pregnancy was two and a half fold (OR 2.49, 95%). ICP was not associated with mother's age, the baby's risk of stillbirth, or low Apgar scores.
ICP mothers are found and taken care of appropriately, and thus ICP is only a minor risk for mothers and their children.
孕妇在初级保健中通过实验室检查筛查肝内胆汁淤积症（ICP）。ICP 病例被转诊至专科治疗。在芬兰，1%的孕妇患有 ICP。本研究旨在探讨分娩结局。设计：回顾性研究 ICP 妊娠。数据来自医院出院登记、患者记录和分娩登记。
芬兰坦佩雷大学医院地区。
总共 687 例 1969 年至 1988 年 ICP 病例，每个病例配 2 个对照。主要观察指标：比较 ICP 患者与对照组的母亲年龄、妊娠次数、分娩时的孕周、引产和剖宫产的频率、住院时间、婴儿体重、阿普加评分和死胎。
对于 ICP 患者，住院 10 天或以上的风险增加 8 倍（OR 8.41），分娩时孕周少于 37 周的风险增加 7 倍（OR 7.02），引产的风险增加 3 倍（OR 3.26），婴儿出生体重低的风险增加近 2 倍（OR 1.86），剖宫产的风险增加 1.5 倍（OR 1.47）。多胎妊娠的可能性增加 2.5 倍（OR 2.49，95%CI）。ICP 与母亲年龄、婴儿死产风险或低阿普加评分无关。
ICP 孕妇得到及时发现和妥善治疗，因此 ICP 对母亲和婴儿的风险较小。
