Naik Mala, Lundervold Arvid, Nygaard Harald, Geitung Jonn-Terje
Departments of Geriatrics and Radiology, Haraldsplass Deaconess Hospital, University of Bergen, Ulriksdal 8, Bergen, Norway.
Acta Radiol. 2010 Jul;51(6):662-8. doi: 10.3109/02841851003709870.
Diffusion tensor imaging (DTI) is a recent MRI technique demonstrating white matter tracts in the brain. Dementia is a neurodegenerative disease and this method has been used to demonstrate the loss of axonal fibers and myelin and decrease of fiber density in this condition.
To study a possible correlation between frontal lobe symptoms in patients with dementia and reduced fractional anisotropy (FA) in white matter/fascicles in the frontal lobes.
The study included 23 patients with dementia and frontal lobe symptoms and 20 controls (10 Alzheimer patients without frontal lobe symptoms and 10 normal controls). Clinical tests and MRI with DTI were performed. FA in subcortical white matter of both the frontal lobes was analyzed and correlated with clinical frontal score tests.
We found a significant correlation between frontal score results and reduction in FA in the frontal lobes. The FA in the study group was significantly lower than the FA in the control group.
The present study reveals that there is a probable correlation between the extent of frontal lobe symptoms and FA in fascicles/white matter tissue in the frontal lobes.
扩散张量成像（DTI）是一种最新的磁共振成像技术，可显示大脑中的白质束。痴呆是一种神经退行性疾病，该方法已被用于证明在这种情况下轴突纤维和髓磷脂的丧失以及纤维密度的降低。
研究痴呆患者额叶症状与额叶白质/束中分数各向异性（FA）降低之间的可能相关性。
该研究包括23例有痴呆和额叶症状的患者以及20名对照（10例无额叶症状的阿尔茨海默病患者和10名正常对照）。进行了临床测试和采用DTI的磁共振成像。分析了双侧额叶皮质下白质的FA，并将其与临床额叶评分测试相关联。
我们发现额叶评分结果与额叶FA降低之间存在显著相关性。研究组的FA显著低于对照组。
本研究表明，额叶症状的程度与额叶束/白质组织中的FA之间可能存在相关性。
