用于基质介导的癌症基因治疗的丝弹性蛋白样蛋白聚合物。

Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy.

机构信息

Department of Bioengineering, University of Utah, Salt Lake City, USA.

出版信息

Adv Drug Deliv Rev. 2010 Dec 30;62(15):1509-23. doi: 10.1016/j.addr.2010.04.006. Epub 2010 Apr 27.

DOI:10.1016/j.addr.2010.04.006

PMID:20430059

Abstract

Silk-elastinlike protein polymers (SELPs) are recombinant polymers designed from silk fibroin and mammalian elastin amino acid repeats. These are versatile materials that have been examined as controlled release systems for intratumoral gene delivery. SELP hydrogels comprise monodisperse and tunable polymers that have the capability to control and localize the release and expression of plasmid DNA and viruses. This article reviews recent developments in the synthesis and characterization of SELP hydrogels and their use for matrix-mediated gene delivery.

摘要

丝弹性蛋白类似蛋白聚合物（SELPs）是由丝素蛋白和哺乳动物弹性蛋白氨基酸重复序列设计而成的重组聚合物。这些是多功能材料，已被作为肿瘤内基因传递的控释系统进行了研究。SELPs 水凝胶由单分散和可调谐的聚合物组成，具有控制和定位质粒 DNA 和病毒释放和表达的能力。本文综述了 SELP 水凝胶的合成和表征及其在基质介导基因传递中的应用的最新进展。