Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Adv Drug Deliv Rev. 2010 Dec 30;62(15):1497-508. doi: 10.1016/j.addr.2010.03.009. Epub 2010 Mar 16.
Silks are biodegradable, biocompatible, self-assembling proteins that can also be tailored via genetic engineering to contain specific chemical features, offering utility for drug and gene delivery. Silkworm silk has been used in biomedical sutures for decades and has recently achieved Food and Drug Administration approval for expanded biomaterials device utility. With the diversity and control of size, structure and chemistry, modified or recombinant silk proteins can be designed and utilized in various biomedical application, such as for the delivery of bioactive molecules. This review focuses on the biosynthesis and applications of silk-based multi-block copolymer systems and related silk protein drug delivery systems. The utility of these systems for the delivery of small molecule drugs, proteins and genes is reviewed.
丝是可生物降解、生物相容的自组装蛋白质，也可以通过基因工程进行定制，以包含特定的化学特征，为药物和基因递送提供了实用性。蚕丝丝已被用于生物医学缝线数十年，最近已获得美国食品和药物管理局批准扩大生物材料设备的实用性。通过改变大小、结构和化学性质的多样性和控制，可以设计和利用经过修饰或重组的丝蛋白在各种生物医学应用中，例如用于递送生物活性分子。本综述重点介绍了基于丝的多嵌段共聚物系统和相关丝蛋白药物递送系统的生物合成和应用。这些系统在小分子药物、蛋白质和基因递送上的应用得到了回顾。
