Institut National de la Santé et de la Recherche Médicale, Hôpital Tenon, Paris, France.
Am J Obstet Gynecol. 2010 Jun;202(6):594.e1-4. doi: 10.1016/j.ajog.2010.03.006. Epub 2010 Apr 28.
The pathogenesis of the HELLP (hemolysis, enzyme liver, low platelets) syndrome is unknown. Recently soluble endoglin (sEng) was identified as a cause of the appearance of schistocytes and liver pathology in an animal model of preeclampsia (PE).
We explored the value of sEng in 82 women who delivered in a context of normal pregnancy (NP, n = 10), PE (n = 49), or HELLP (n = 23).
sEng was elevated in pathological pregnancies (66.7 +/- 62 and 75.7 +/- 48 pg/mL in PE and HELLP, respectively, vs 5.29 +/- 1.25 in NP, P < .001 for both comparisons) and was correlated with an increase in transaminases (r(2) = 0.17; P = .05), but it was not statistically different between PE and HELLP.
Although recent literature findings demonstrated a role of sEng in the pathophysiology of HELLP syndrome in animal models, we found that, at the time of delivery, sEng was not specifically elevated in preeclamptic patients with HELLP.
HELLP（溶血、肝酶升高、血小板减少）综合征的发病机制尚不清楚。最近，可溶性内皮糖蛋白（sEng）被鉴定为先兆子痫（PE）动物模型中出现裂体细胞和肝病理的原因。
我们研究了 82 名分娩妇女的可溶性内皮糖蛋白（sEng）水平，其中包括正常妊娠（NP，n=10）、PE（n=49）和 HELLP（n=23）。
sEng 在病理性妊娠中升高（PE 和 HELLP 分别为 66.7 +/- 62 和 75.7 +/- 48 pg/mL，NP 为 5.29 +/- 1.25，两者均 P <.001），与转氨酶升高相关（r²=0.17；P=0.05），但在 PE 和 HELLP 之间无统计学差异。
尽管最近的文献发现 sEng 在动物模型中对 HELLP 综合征的病理生理学有作用，但我们发现，在分娩时，HELLP 子痫前期患者的 sEng 并没有特异性升高。
