Salford Royal Foundation Trust, Stott Lane, Salford, Lancashire M6 8HD, United Kingdom.
Seizure. 2010 Jun;19(5):261-3. doi: 10.1016/j.seizure.2010.02.011. Epub 2010 Apr 28.
To assess the effect of the duration of epilepsy on the outcome of epilepsy surgery in non-lesional medically refractory temporal lobe epilepsy we reviewed the outcome of 76 patients.
All patients had anterior temporal resections for "non-lesional" temporal epilepsy (excluding any patient with tumours or vascular malformations but including patients with hippocampal sclerosis). Outcome at one year was assessed using Engel's scale.
67% had a good outcome (Engel I or II). The mean duration of epilepsy was 23.0 years (range 2.9-46.9 years). Overall, there was no significant difference between patients with good outcome (mean duration 22.4 years) and poor outcome (mean duration 24.2 years) (p=0.49). The proportion of patients with good outcome was slightly higher in the shorter duration groups. (Duration less than 10 years 75%, 10-19 years 71%, 20-29 years 65%, 30-39 years 62%, and 40-49 years 60% good outcome, p=0.95).
We found no significant associations between outcome and duration of epilepsy.
评估癫痫持续时间对非病变性药物难治性颞叶癫痫手术结果的影响，我们回顾了 76 例患者的结果。
所有患者均因“非病变性”颞叶癫痫行前颞叶切除术（不包括任何肿瘤或血管畸形患者，但包括海马硬化患者）。术后 1 年采用 Engel 量表评估结果。
67%的患者预后良好（Engel I 或 II 级）。癫痫的平均持续时间为 23.0 年（范围 2.9-46.9 年）。总体而言，预后良好组（平均持续时间 22.4 年）和预后不良组（平均持续时间 24.2 年）之间无显著差异（p=0.49）。在较短持续时间组中，预后良好的患者比例略高。（持续时间<10 年为 75%，10-19 年为 71%，20-29 年为 65%，30-39 年为 62%，40-49 年为 60%，p=0.95）。
我们发现手术结果与癫痫持续时间之间无显著关联。
