Bakare Tajudeen I B, Badmus T A, Lawal A O, Katung A I
Department of Surgery, Federal Medical Centre, Owo, Ondo State, Nigeria.
Afr J Paediatr Surg. 2010 May-Aug;7(2):71-4. doi: 10.4103/0189-6725.62846.
The discrepancy in diameters of the resected ends coupled with the heavy faecal loads in the colon of chronically constipated children with Hirschsprung's disease makes definitive primary pull-through procedure quite difficulty in this group.
Four consecutive patients (aged 5 months to 11 years) who presented with chronic constipation were given warm saline enema along with Castor oil per oram twice daily for 1 week before and 2 weeks after full-thickness biopsies that confirmed Hirschsprung's disease. All patients had intravenous Cefuroxime or Ceftriaxone plus Metronidazole at induction of anaesthesia. Intra-operatively, the levels of resections were 6-8 cm proximal to the most contractile part of the colon adjacent to the transition zone observed after complete division of mesenteric vessels.
There were three males and one female, aged 5 months to 11 years. The levels of aganglionosis were in the rectosigmoid region, except one in the descending colon. There was one case each of anastomotic stenoses, mild enterocolitis and deep peri-anal excoriation. The bowel motions were two to four times daily within 1 month post-operatively.
It can be concluded from this preliminary study that with pre-operative saline enema and oral Castor oil for about 3 weeks in chronically constipated children with Hirschsprung's disease primary pull-through procedures can be performed successfully. However, further prospective work is required with this method.
患有先天性巨结肠症的慢性便秘儿童,其结肠切除端直径存在差异,且结肠内粪便负荷较重,这使得该群体进行确定性一期拖出术颇具难度。
连续4例(年龄5个月至11岁)表现为慢性便秘的患者,在全层活检确诊先天性巨结肠症之前1周及之后2周,每天两次口服蓖麻油并给予温盐水灌肠。所有患者在麻醉诱导时静脉给予头孢呋辛或头孢曲松加甲硝唑。术中,在肠系膜血管完全离断后,切除水平为距结肠与移行区相邻的最收缩部位近端6 - 8厘米处。
有3名男性和1名女性,年龄5个月至11岁。除1例在降结肠外,无神经节细胞症水平均在直肠乙状结肠区域。分别有1例出现吻合口狭窄、轻度小肠结肠炎和肛周深度擦伤。术后1个月内每天排便2至4次。
从这项初步研究可以得出结论,对于患有先天性巨结肠症的慢性便秘儿童,术前给予盐水灌肠和口服蓖麻油约3周,可以成功进行一期拖出术。然而,需要对该方法进行进一步的前瞻性研究。