Speisky H, Cassels B K, Lissi E A, Videla L A
Facultad de Química, Pontificia Universidad Católica, Santiago, Chile.
Biochem Pharmacol. 1991 Jun 1;41(11):1575-81. doi: 10.1016/0006-2952(91)90156-y.
Boldine, in low micromolar concentrations, was able to prevent brain homogenate autooxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection.
在低微摩尔浓度下，波尔定碱能够防止脑匀浆自动氧化、2,2'-偶氮二(2-脒基丙烷)(AAP)诱导的红细胞质膜脂质过氧化以及AAP诱导的溶菌酶失活。这些结果表明波尔定碱对自由基具有高反应活性。对波尔定碱效应随孵育时间的分析表明，波尔定碱与自由基相互作用产生的一种代谢产物也具有抗氧化活性，在脑匀浆自动氧化中比波尔定碱更有效，而在溶菌酶保护实验中效率较低。这种行为可以根据提供最大保护所需清除剂的相对位置来解释。
