Capanlar Seval, Böke Nazli, Yaşa Ihsan, Kirmizigül Süheyla
Chemistry Department, Faculty of Science, Ege University, Bornova, Izmir, Turkey.
Nat Prod Commun. 2010 Apr;5(4):563-6.
A novel glycoside, hirsutusoide (1), characterized as 2-(o-hydroxyphenyl)-2-hydroxyethenyl-O-beta-glucopyranoside, was isolated from the endemic Acanthus hirsutus Boiss. In addition to compound 1, three known glycosides, luteolin-7-O-beta-D-glucuronide (2), beta-sitosterol-3-O-beta-D-glucopyranoside (3) and (2R)-2-O-beta-D-glucopyranosyl-2H-1,4-benzoxazin-3(4H)-one (4), were also isolated. Compound 2 was the first report from this genus. Antimicrobial and antioxidant activity of the extracts and the novel compound were investigated by determining MIC (microg/mL) and IC50 (microg/mL) values, respectively.
从当地特有的硬毛老鼠簕（Acanthus hirsutus Boiss.）中分离出一种新型糖苷——硬毛鼠簕苷（1），其结构鉴定为2-(邻羟基苯基)-2-羟基乙烯基-O-β-D-吡喃葡萄糖苷。除化合物1外，还分离出三种已知糖苷，分别为木犀草素-7-O-β-D-葡萄糖醛酸苷（2）、β-谷甾醇-3-O-β-D-吡喃葡萄糖苷（3）和(2R)-2-O-β-D-吡喃葡萄糖基-2H-1,4-苯并恶嗪-3(4H)-酮（4）。化合物2是该属的首次报道。通过分别测定最低抑菌浓度（MIC，μg/mL）和半数抑制浓度（IC50，μg/mL）值，对提取物和新型化合物的抗菌和抗氧化活性进行了研究。
