Sure Durga, Dunn Ian, Norden Andrew, Anderson William S
Clin Neurol Neurosurg. 2010 Oct;112(8):741-2. doi: 10.1016/j.clineuro.2010.04.005.
Thrombocytopenia related intracerebral hemorrhage (ICH) secondary to chemotherapy induced myelosuppression can be very difficult to manage and may result in the death of the patient. We present the case of a 26-year-old male suffering a fatal ICH in the context of treatment of a high grade glioma with temozolomide. The clinician should be aware that a dose dependent severe and possible irreversible myelotoxicity can occur with temozolomide treatment resulting in substantial morbidity.
化疗引起骨髓抑制继发的血小板减少性脑出血（ICH）可能很难处理，甚至可能导致患者死亡。我们报告了一例26岁男性在使用替莫唑胺治疗高级别胶质瘤时发生致命性脑出血的病例。临床医生应意识到，替莫唑胺治疗可能会出现剂量依赖性的严重且可能不可逆的骨髓毒性，从而导致严重的发病情况。
