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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pavlic M R, Wilson I B

Biochim Biophys Acta. 1978 Mar 14;523(1):101-8. doi: 10.1016/0005-2744(78)90013-x.

In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. 2. The results showed that the accelerator accelerates the reaction by electrostatically improving the binding between acetylcholinesterase and methanesulfonylfluoride without effecting the rate of the decomposition of the enzyme-inhibitor complex into the methanesulfonylated enzyme and product.

为了阐明阳离子促进剂加速乙酰胆碱酯酶（乙酰胆碱水解酶，EC 3.1.1.7）甲磺酰化作用机制的某些特征，研究了在不存在和存在促进剂十烃季铵和四乙铵的情况下，高浓度甲磺酰氟对该酶的甲磺酰化作用。2. 结果表明，促进剂通过静电作用改善乙酰胆碱酯酶与甲磺酰氟之间的结合来加速反应，而不影响酶-抑制剂复合物分解为甲磺酰化酶和产物的速率。

Pavlic M R, Wilson I B

Biochim Biophys Acta. 1978 Mar 14;523(1):101-8. doi: 10.1016/0005-2744(78)90013-x.

In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. 2. The results showed that the accelerator accelerates the reaction by electrostatically improving the binding between acetylcholinesterase and methanesulfonylfluoride without effecting the rate of the decomposition of the enzyme-inhibitor complex into the methanesulfonylated enzyme and product.

为了阐明阳离子促进剂加速乙酰胆碱酯酶（乙酰胆碱水解酶，EC 3.1.1.7）甲磺酰化作用机制的某些特征，研究了在不存在和存在促进剂十烃季铵和四乙铵的情况下，高浓度甲磺酰氟对该酶的甲磺酰化作用。2. 结果表明，促进剂通过静电作用改善乙酰胆碱酯酶与甲磺酰氟之间的结合来加速反应，而不影响酶-抑制剂复合物分解为甲磺酰化酶和产物的速率。