Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.
Am J Obstet Gynecol. 2010 Aug;203(2):107.e1-7. doi: 10.1016/j.ajog.2010.03.004. Epub 2010 May 1.
The objective of the study was to characterize women undergoing a termination of pregnancy (TOP) during the second trimester and to evaluate the risk factors and timing of repeat TOP.
This nationwide retrospective cohort study investigated 41,750 women who underwent TOP during the first (n = 39,850) or second (n = 1900) trimester in Finland in 2000-2005. The follow-up time was until repeat TOP or until Dec. 31, 2006.
TOP during the second trimester increases the risk of repeat TOP (hazard ratio [HR], 1.4; 95% confidence interval [CI], 1.3-1.6), repeat second-trimester TOP (HR, 3.8; 95% CI, 2.9-5.1), and repeat TOP after 16 weeks of gestation (HR, 5.0; 95% CI, 3.3-7.7). The other risk factor for these is young age (HR, 7.0, 95% CI, 5.3-9.3; and HR, 12.5; 95% CI, 3.1-50.4 for age <20 years).
Second-trimester TOP and young age are risk factors for repeat second-trimester TOP. Special focus on these women might be effective in decreasing repeat abortions.
本研究旨在描述接受中期妊娠终止（TOP）的女性，并评估其重复 TOP 的风险因素和时间。
这项全国性回顾性队列研究调查了 2000 年至 2005 年在芬兰接受第一孕期（n = 39,850）或第二孕期（n = 1900）TOP 的 41,750 名女性。随访时间直到重复 TOP 或直到 2006 年 12 月 31 日。
第二孕期 TOP 增加了重复 TOP（风险比 [HR]，1.4；95%置信区间 [CI]，1.3-1.6）、重复第二孕期 TOP（HR，3.8；95% CI，2.9-5.1）和 16 周后妊娠终止（HR，5.0；95% CI，3.3-7.7）的风险。这些的另一个风险因素是年龄较小（HR，7.0，95% CI，5.3-9.3；HR，12.5；95% CI，3.1-50.4，年龄 <20 岁）。
第二孕期 TOP 和年轻是重复第二孕期 TOP 的风险因素。对这些女性的特别关注可能有助于减少重复流产。
