Institute of Psychiatry, Kings Health Partners, London, UK.
Br J Psychiatry. 2010 May;196(5):372-6. doi: 10.1192/bjp.bp.109.066050.
Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure.
To assess the long-term effect of early intervention in psychosis.
Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874). Outcome after 5 years was assessed by case-note review.
There were no significant differences in the admission rate (coefficient 0.096, 95% CI -0.550 to 0.742, P = 0.770) or the mean number of bed days (coefficient 6.344, 95% CI -46 to 58.7, P = 0.810).
These findings that specialist intervention did not markedly improved outcome at 5 years accord with those from a larger OPUS study. The sample size of this study was small and these results should be generalised with caution. More research is needed.
早期的专业治疗可能会改善首发非情感性精神病患者的短期预后，但这些益处是否持久尚不清楚。
评估精神病早期干预的长期效果。
首发精神病患者被随机分配到专门护理组或常规护理组（试验编号：ISRCTN73679874）。通过病历回顾评估 5 年后的结果。
入院率（系数 0.096，95%CI-0.550 至 0.742，P=0.770）或平均住院天数（系数 6.344，95%CI-46 至 58.7，P=0.810）均无显著差异。
这些发现表明，在 5 年时，专家干预并没有显著改善预后，与 OPUS 更大规模的研究结果一致。本研究的样本量较小，这些结果应谨慎推广。需要更多的研究。
