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一名HIV阳性患者的肾移植

Renal transplantation in a HIV positive patient.

作者信息

Mann A, Soundararajan P, Shroff S

机构信息

Department of Nephrology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, India.

出版信息

Indian J Nephrol. 2009 Jul;19(3):119-21. doi: 10.4103/0971-4065.57110.

DOI:10.4103/0971-4065.57110
PMID:20436733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2859478/
Abstract

Historically HIV positive patients were considered a contraindication for renal transplant. After the year 1996, with the introduction of HAART the retropositive patients live longer and therefore end stage organ disease is now an increasingly important cause of mortality and morbidity in these patients. Here we report our experience for the first time in India. A forty nine year old hypertensive female from Africa who was diagnosed chronic kidney disease and retropositive status, progressed to end stage renal disease and underwent live related renal transplant at our centre.

摘要

历史上,HIV阳性患者被视为肾移植的禁忌证。1996年后,随着高效抗逆转录病毒疗法(HAART)的引入,HIV阳性患者的寿命延长,因此终末期器官疾病现在已成为这些患者死亡和发病的一个日益重要的原因。在此,我们首次报告我们在印度的经验。一名来自非洲的49岁高血压女性,被诊断为慢性肾病且HIV阳性,病情进展至终末期肾病,并在我们中心接受了活体亲属肾移植。

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本文引用的文献

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When to initiate antiretroviral therapy in HIV-1-infected adults: a review for clinicians and patients.HIV-1感染成人何时开始抗逆转录病毒治疗:给临床医生和患者的一份综述
Lancet Infect Dis. 2005 Jul;5(7):407-14. doi: 10.1016/S1473-3099(05)70162-6.
2
Antiretroviral and immunosuppressive drug-drug interactions: an update.
Kidney Int. 2004 Aug;66(2):532-41. doi: 10.1111/j.1523-1755.2004.00772.x.
3
Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study.人类免疫缺陷病毒感染患者的肾和肝移植:一项安全性和有效性的试点研究。
Transplantation. 2003 Jul 27;76(2):370-5. doi: 10.1097/01.TP.0000075973.73064.A6.
4
Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient.长期非进展性HIV感染受者的肾胰联合移植
Am J Transplant. 2003 May;3(5):631-3. doi: 10.1034/j.1600-6143.2003.00119.x.
5
Review of solid-organ transplantation in HIV-infected patients.
Transplantation. 2003 Feb 27;75(4):425-9. doi: 10.1097/01.TP.0000046943.35335.18.
6
Drug interactions between antiretroviral drugs and comedicated agents.抗逆转录病毒药物与合并使用药物之间的药物相互作用。
Clin Pharmacokinet. 2003;42(3):223-82. doi: 10.2165/00003088-200342030-00002.
7
Solid-organ transplantation in HIV-infected patients.HIV感染患者的实体器官移植
N Engl J Med. 2002 Jul 25;347(4):284-7. doi: 10.1056/NEJMsb020632.
8
[Kidney transplantation in a patient with HIV infection discovered during transplantation. Initial course].[移植术中发现HIV感染患者的肾移植。初始病程]
Nefrologia. 2002;22(3):298-300.
9
Clinical pharmacokinetics of non-nucleoside reverse transcriptase inhibitors.非核苷类逆转录酶抑制剂的临床药代动力学
Clin Pharmacokinet. 2001;40(12):893-905. doi: 10.2165/00003088-200140120-00002.
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Transplantation. 2001 Jul 27;72(2):177-81. doi: 10.1097/00007890-200107270-00001.