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用 940nm 激光行睫状体光凝术治疗非洲人原发性开角型青光眼。

Controlled cyclophotocoagulation with the 940 nm laser for primary open angle glaucoma in African eyes.

机构信息

Universitats-Augenklinik, Langenbeckstr. 1, 55101, Mainz, Germany.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2010 Oct;248(10):1473-9. doi: 10.1007/s00417-010-1363-4. Epub 2010 May 2.

Abstract

BACKGROUND

"Controlled cyclophotocoagulation" is a real-time dosage control which reduces the complications of transscleral cyclophotocoagulation to a negligible amount in European eyes. Applied to a few African eyes, however, the method failed. Obviously, the physical parameters of the laser procedure need adjustment to African eyes.

METHOD AND MATERIAL

After theoretical investigations and tests in African cadaver eyes, 940 nm laser wavelength instead of 810 nm and a different fiber coupling had solved the problem of physical differences between European and African eyes to a large extent. The method was then applied to 272 eyes of 188 patients with primary open-angle glaucoma, of which it was possible to follow 26 eyes of 18 patients for at least 1 year. Median age of the patients was 63.7 years, with the youngest 16.8 years, the oldest 88.8 years. Either 16 or 24 laser spots were applied at random. If both eyes were treated, they were treated in the same session.

RESULTS

The average intraocular pressure (IOP) reduction after 1 year was 7.5 mmHg, with average glaucoma drug reduction from 1.5 to 1.2 substances. At least one pop spot occurred in 32% of the eyes. No statistically significant difference between 16 and 24 spots was found. No severe complications such as intraocular bleeding, hypotony <7 mmHg, choroidal detachment or phthisis were observed.

CONCLUSION

Controlled cyclophotocoagulation with the 940 nm laser is a safe method which can be applied as the first-choice treatment to African primary open-angle glaucoma eyes. Individual IOP prediction, however, is very difficult.

摘要

背景

“可控的环光凝术”是一种实时剂量控制方法,可将巩膜环光凝术的并发症降低到在欧洲眼睛中微不足道的程度。然而,将该方法应用于少数非洲眼睛时却失败了。显然,激光手术的物理参数需要针对非洲眼睛进行调整。

方法和材料

在对非洲尸体眼球进行了理论研究和测试后,我们使用 940nm 激光波长代替 810nm,并采用了不同的光纤耦合,在很大程度上解决了欧洲和非洲眼睛之间的物理差异问题。然后,我们将该方法应用于 188 例原发性开角型青光眼患者的 272 只眼中,其中有 18 例患者的 26 只眼可以至少随访 1 年。患者的中位年龄为 63.7 岁,最小年龄为 16.8 岁,最大年龄为 88.8 岁。随机应用 16 或 24 个激光点。如果双眼均接受治疗,则在同一治疗中进行。

结果

治疗 1 年后,平均眼压(IOP)降低了 7.5mmHg,平均青光眼药物从 1.5 种减少到 1.2 种。至少有 1 个光斑出现在 32%的眼中。16 个和 24 个光斑之间没有发现统计学上的显著差异。没有观察到严重的并发症,如眼内出血、眼压<7mmHg、脉络膜脱离或眼球萎缩。

结论

940nm 激光的可控环光凝术是一种安全的方法,可作为非洲原发性开角型青光眼眼的首选治疗方法。然而,个体眼压预测非常困难。

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