Department of Internal Medicine, Medical Faculty, P.J. Safárik University Kosice, Trieda SNP 1, 04011, Kosice, Slovakia.
Clin Rheumatol. 2010 Nov;29(11):1327-30. doi: 10.1007/s10067-010-1426-2. Epub 2010 May 2.
Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH analogs are extensively used in in vitro fertilization and treatment of sex hormone-dependent cancers due to their ability to bring about 'chemical castration'. Recently it has been showed that it also plays an important role in the modulation of the immune system. We report a case of vasculitis and histologically proven severe polymyositis developed 5 days after GnRH administration due to ovulation induction in an infertile patient with no previous history of autoimmune diseases. After treatment with corticosteroids (prednisone, 30 mg daily), aspirin, and pentoxyphyllin in combination with rehabilitation, an amelioration of muscle impairment was observed.
促性腺激素释放激素（GnRH）是生殖的第一关键激素。由于 GnRH 类似物能够实现“化学去势”，因此被广泛应用于体外受精和治疗性激素依赖性癌症。最近研究表明，它在免疫系统的调节中也发挥着重要作用。我们报告了一例因排卵诱导而导致的血管炎和组织学证实的严重多发性肌炎，该患者为不孕患者，无自身免疫性疾病史，在 GnRH 给药后 5 天发病。给予泼尼松（每日 30mg）、阿司匹林和己酮可可碱联合康复治疗后，肌肉损伤得到改善。
