Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Ann Neurol. 2010 May;67(5):689-93. doi: 10.1002/ana.21989.
Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
抑制性神经甾体,是由循环类固醇激素和胆固醇从头合成的胶质细胞产生的分子,可以控制癫痫动物的癫痫发作。它们可以增强γ-氨基丁酸受体介导的抑制性传递,并具有抗惊厥作用。