内源性神经甾体合成调节癫痫发作频率。
Endogenous neurosteroid synthesis modulates seizure frequency.
机构信息
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
出版信息
Ann Neurol. 2010 May;67(5):689-93. doi: 10.1002/ana.21989.
Abstract
Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
摘要
抑制性神经甾体，是由循环类固醇激素和胆固醇从头合成的胶质细胞产生的分子，可以控制癫痫动物的癫痫发作。它们可以增强γ-氨基丁酸受体介导的抑制性传递，并具有抗惊厥作用。
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