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内源性神经甾体合成调节癫痫发作频率。

Endogenous neurosteroid synthesis modulates seizure frequency.

机构信息

Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.

出版信息

Ann Neurol. 2010 May;67(5):689-93. doi: 10.1002/ana.21989.

DOI:10.1002/ana.21989
PMID:20437568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2918659/
Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

摘要

抑制性神经甾体，是由循环类固醇激素和胆固醇从头合成的胶质细胞产生的分子，可以控制癫痫动物的癫痫发作。它们可以增强γ-氨基丁酸受体介导的抑制性传递，并具有抗惊厥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4300/2918659/bdb6719f63b9/nihms220415f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4300/2918659/bdb6719f63b9/nihms220415f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4300/2918659/bdb6719f63b9/nihms220415f1.jpg

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本文引用的文献

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The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy.神经甾体在月经性癫痫的病理生理学及治疗中的作用。
Epilepsy Res. 2009 Jul;85(1):1-30. doi: 10.1016/j.eplepsyres.2009.02.017. Epub 2009 Apr 29.
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Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.神经甾体研究XXV. 5α-还原酶抑制剂非那雄胺对大鼠脑内神经甾体水平及代谢的影响。
Biol Pharm Bull. 2008 Sep;31(9):1646-50. doi: 10.1248/bpb.31.1646.
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Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy.
在小鼠反复低剂量红藻氨酸全身注射模型中，性别和性腺切除术会改变行为性癫痫易感性及死亡率。
bioRxiv. 2023 Aug 2:2023.05.22.541824. doi: 10.1101/2023.05.22.541824.
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Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures.癫痫发作诱导的神经肽Y过表达在自发性复发性癫痫小鼠模型中诱导癫痫耐受性。
Front Mol Neurosci. 2022 Oct 13;15:974784. doi: 10.3389/fnmol.2022.974784. eCollection 2022.
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Limbic progesterone receptor activity enhances neuronal excitability and seizures.边缘系统孕激素受体活性增强神经元兴奋性和癫痫发作。
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