DNA 和环糊精固定化聚（亚乙基胺）复合材料：从多组分溶液中积累有害化合物。

Composite material of DNA and cyclodextrin-immobilized poly(ethyleneimine): Accumulation of harmful compounds from multi-component solution.

机构信息

Department of Chemistry, Faculty of Science, Okayama University of Science, Ridaicho 1-1, Kita-Ku, Okayama 700-0005, Japan.

出版信息

Int J Biol Macromol. 2010 Aug 1;47(2):201-6. doi: 10.1016/j.ijbiomac.2010.04.021. Epub 2010 May 11.

DOI:10.1016/j.ijbiomac.2010.04.021

PMID:20438752

Abstract

Water-soluble beta-cyclodextrin-immobilized poly(ethyleneimine) (PEICD) was synthesized by the grafting of beta-cyclodextrin to the branched poly(ethyleneimine). In an aqueous solution, this PEICD polymer could encapsulate bisphenol A, known to be a harmful compound. Additionally, the stability constant of bisphenol A to the PEICD polymer was 1.1 x 10(4)M(-1). However, the water-solubility of PEICD has been making it difficult to utilize it as an environmental material. Therefore, we prepared the DNA-PEICD composite material by mixing the double-stranded DNA and PEICD. This DNA-PEICD composite material was extremely stable in water and possessed both properties of the intercalation into the double-stranded DNA and the encapsulation into the CD cavity. As a result, this material can accumulate various harmful compounds, such as dioxin- and polychlorobiphenyl (PCB)-derivatives and bisphenol A, from a multi-component solution. Therefore, the DNA-PEICD composite material may have the potential to be used as an environmental material.

摘要

水溶性β-环糊精接枝的聚（亚乙基亚胺）（PEICD）是通过β-环糊精接枝到支化聚（亚乙基亚胺）上合成的。在水溶液中，这种 PEICD 聚合物可以包裹双酚 A，已知双酚 A 是一种有害化合物。此外，双酚 A 与 PEICD 聚合物的稳定常数为 1.1 x 10(4)M(-1)。然而，PEICD 的水溶性使其难以用作环境材料。因此，我们通过混合双链 DNA 和 PEICD 制备了 DNA-PEICD 复合材料。这种 DNA-PEICD 复合材料在水中极其稳定，同时具有插入双链 DNA 和包裹 CD 腔的性质。因此，这种材料可以从多组分溶液中积累各种有害物质，如二恶英和多氯联苯（PCB）衍生物以及双酚 A。因此，DNA-PEICD 复合材料可能有潜力用作环境材料。