分析摩洛哥人群中 MIF、FCGR2A 和 FCGR3A 基因多态性与肺结核易感性的关系。
Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population.
机构信息
Human Genomic Unit, Laboratory of Immunology, National Institute of Hygiene, Rabat 10000, Morocco.
出版信息
J Genet Genomics. 2010 Apr;37(4):257-64. doi: 10.1016/S1673-8527(09)60044-8.
In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor (MIF), Fcg receptors CD16A (FCGR3A) and CD32A (FCGR2A) genes on susceptibility to pulmonary tuberculosis (PTB) in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for MIF-173 (G/C) (rs755622), FCGR2A-131H/R (rs1801274) and FCGR3A-158V/F (rs396991) was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant increase of the MIF -173CC homozygote genotype and MIF -173C allele frequencies in PTB patients compared with healthy controls (17.07%versus 5.84%, P = 0.003; and 35.37%versus 26.30%, P = 0.02; respectively). In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that MIF -173C variant may play an important role in the development of active tuberculosis.
为了研究巨噬细胞移动抑制因子（MIF）、Fc 受体 CD16A（FCGR3A）和 CD32A（FCGR2A）基因的功能多态性对摩洛哥人群肺结核（PTB）易感性的影响，我们分析了 123 例 PTB 患者和 154 例健康对照者。采用 TaqMan SNP 基因分型检测方法对 MIF-173（G/C）（rs755622）、FCGR2A-131H/R（rs1801274）和 FCGR3A-158V/F（rs396991）进行基因分型。我们发现 PTB 患者 MIF-173CC 纯合基因型和 MIF-173C 等位基因频率明显高于健康对照组（17.07%比 5.84%，P = 0.003；35.37%比 26.30%，P = 0.02）。相反，FCGR2A-131H/R 和 FCGR3A-158V/F 多态性与结核病之间无相关性。我们的研究结果表明，MIF-173C 变异可能在活动性肺结核的发生中起重要作用。
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