Clinical Genetics, Department of Pediatrics, Hospital de Cruces, Barakaldo, Spain.
Pediatrics. 2010 Jun;125(6):e1514-7. doi: 10.1542/peds.2009-2795. Epub 2010 May 3.
We report here the case of a child with a known muscular abnormality and susceptibility to malignant hyperthermia who abruptly died after receiving a therapeutic dose of ondansetron. Also, we discuss the pharmacodynamic relationship of ondansetron to malignant hyperthermia in a susceptible host.
我们在此报告一例已知肌肉异常和恶性高热易感性的儿童,在接受奥氮平治疗剂量后突然死亡。此外,我们还讨论了奥氮平在易感宿主中与恶性高热的药效学关系。