Stanford and Sunnyvale, Calif. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford University; the Department of Bioengineering, Stanford University; and Spiracur, Inc.
Plast Reconstr Surg. 2010 May;125(5):1362-1371. doi: 10.1097/PRS.0b013e3181d62b25.
Negative-pressure wound therapy is traditionally achieved by attaching an electrically powered pump to a sealed wound bed and applying subatmospheric pressure by means of gauze or foam. The Smart Negative Pressure (SNaP) System (Spiracur, Inc., Sunnyvale, Calif.) is a novel ultraportable negative-pressure wound therapy system that does not require an electrically powered pump.
Negative pressure produced by the SNaP System, and a powered pump, the wound vacuum-assisted closure advanced-therapy system (Kinetic Concepts, Inc., San Antonio, Texas), were compared in vitro using bench-top pressure sensor testing and microstrain and stress testing with pressure-sensitive film and micro-computed tomographic scan analysis. In addition, to test in vivo efficacy, 10 rats underwent miniaturized SNaP (mSNaP) device placement on open wounds. Subject rats were randomized to a system activation group (approximately -125 mmHg) or a control group (atmospheric pressure). Wound measurements and histologic data were collected for analysis.
Bench measurement revealed nearly identical negative-pressure delivery and mechanical strain deformation patterns between both systems. Wounds treated with the mSNaP System healed faster, with decreased wound size by postoperative day 7 (51 percent versus 12 percent reduction; p < 0.05) and had more rapid complete reepithelialization (21 days versus 32 days; p < 0.05). The mSNaP device also induced robust granulation tissue formation.
The SNaP System and an existing electrically powered negative-pressure wound therapy system have similar biomechanical properties and functional wound-healing benefits. The potential clinical efficacy of the SNaP device for the treatment of wounds is supported.
负压伤口疗法传统上是通过将电动泵连接到密封的伤口床上，并通过纱布或泡沫施加低于大气压的压力来实现的。Smart Negative Pressure（SNaP）系统（Spiracur，Inc.，加利福尼亚州桑尼维尔）是一种新型超便携负压伤口治疗系统，不需要电动泵。
使用台式压力传感器测试、压力敏感膜和微计算机断层扫描分析的微应变和应力测试，对 SNaP 系统和电动泵产生的负压进行了体外比较。此外，为了测试体内疗效，10 只大鼠在开放性伤口上进行了微型 SNaP（mSNaP）装置的放置。受测大鼠随机分为系统激活组（约-125mmHg）或对照组（大气压）。收集伤口测量和组织学数据进行分析。
台架测量显示，两种系统的负压输送和机械应变变形模式几乎相同。用 mSNaP 系统治疗的伤口愈合更快，术后第 7 天伤口面积减小（51%比 12%减少；p<0.05），完全上皮化更快（21 天比 32 天；p<0.05）。mSNaP 装置还诱导了丰富的肉芽组织形成。
SNaP 系统和现有的电动负压伤口治疗系统具有相似的生物力学特性和功能伤口愈合益处。支持 SNaP 装置治疗伤口的潜在临床疗效。
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