Murata M, Takayama K, Nagashima Y
Division of Epidemiology, Chiba Cancer Center Research Institute, Japan.
Cancer Detect Prev. 1991;15(1):69-75.
This study was aimed at examining the effect of familial predisposition on cancer incidence in a cohort population. Family history (FH) of cancer and reproductive history were obtained by a simple questionnaire from about 40,000 participants in a cervical cancer screening program visiting screening clinics in 1977. Number and age structure of family members were not known. About 40% of subjects reported positive FH which was not medically verified. Comparing the observed and expected numbers of pair-wise combination of various cancers observed among the family members, we found more intense cluster of cancers of the same than different sites. This population was followed until 1987 by using the population-based cancer registry and 638 cancer cases were detected. By matching residence and birth year, the same number of nonaffected controls was chosen from the original cohorts. Positive effect of FH was detected for large bowel and breast cancers, but not for stomach and cervical cancers. Older age at marriage and lower parity were noted for breast cancer cases.
本研究旨在调查队列人群中家族易感性对癌症发病率的影响。通过一份简单问卷，从1977年前往筛查诊所参加宫颈癌筛查项目的约40000名参与者中获取癌症家族史（FH）和生育史。家庭成员的数量和年龄结构未知。约40%的受试者报告有阳性家族史，但未经医学验证。通过比较家庭成员中观察到的各种癌症两两组合的观察数和预期数，我们发现相同部位癌症的聚集比不同部位更为明显。利用基于人群的癌症登记系统对该人群进行随访，直至1987年，共检测到638例癌症病例。通过匹配居住地和出生年份，从原始队列中选取相同数量的未受影响对照。发现家族史对大肠癌和乳腺癌有阳性影响，但对胃癌和宫颈癌没有影响。乳腺癌病例的结婚年龄较大且产次较低。
