New York State Psychiatric Institute, New York, New York, USA.
Psychol Med. 2010 Jun;40(6):977-88. doi: 10.1017/S0033291709991231.
To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States.
Data came from a large representative sample of the US population. Face-to-face interviews of 43093 adults residing in households were conducted during 2001-2002. Diagnoses of mood, anxiety, alcohol and drug use disorders and personality disorders were based on the Alcohol Use Disorder and Associated Disabilities Interview Schedule - DSM-IV version.
Lifetime prevalence of co-morbid AUD and SAD in the general population was 2.4%. SAD was associated with significantly increased rates of alcohol dependence [odds ratio (OR) 2.8] and alcohol abuse (OR 1.2). Among respondents with alcohol dependence, SAD was associated with significantly more mood, anxiety, psychotic and personality disorders. Among respondents with SAD, alcohol dependence and abuse were most strongly associated with more substance use disorders, pathological gambling and antisocial personality disorders. SAD occurred before alcohol dependence in 79.7% of co-morbid cases, but co-morbidity status did not influence age of onset for either disorder. Co-morbid SAD was associated with increased severity of alcohol dependence and abuse. Respondents with co-morbid SAD and alcohol dependence or abuse reported low rates of treatment-seeking.
Co-morbid lifetime AUD and SAD is a prevalent dual diagnosis, associated with substantial rates of additional co-morbidity, but remaining largely untreated. Future research should clarify the etiology of this co-morbid presentation to better identify effective means of intervention.
评估美国成年人全国代表性样本中并存的社交焦虑障碍(SAD)和酒精使用障碍(AUD,即酒精滥用和酒精依赖)的患病率和临床影响。
数据来自美国的大型代表性样本。2001-2002 年对居住在家庭中的 43093 名成年人进行了面对面访谈。基于酒精使用障碍和相关障碍访谈时间表-DSM-IV 版本对心境、焦虑、酒精和药物使用障碍以及人格障碍进行了诊断。
普通人群中并存的 AUD 和 SAD 的终生患病率为 2.4%。SAD 与酒精依赖(比值比[OR]2.8)和酒精滥用(OR 1.2)的发生率显著增加相关。在有酒精依赖的受访者中,SAD 与更多的心境障碍、焦虑障碍、精神病性障碍和人格障碍显著相关。在有 SAD 的受访者中,酒精依赖和滥用与更多的物质使用障碍、病态赌博和反社会人格障碍的关系最密切。在并存病例中,79.7%的 SAD 先于酒精依赖,但共存状态并不影响任何一种疾病的发病年龄。并存的 SAD 与酒精依赖和滥用的严重程度增加有关。患有并存的 SAD 和酒精依赖或滥用的受访者报告的寻求治疗的比例较低。
终生并存的 AUD 和 SAD 是一种常见的双重诊断,与额外共病的高发病率相关,但仍未得到充分治疗。未来的研究应阐明这种共病表现的病因,以更好地确定有效的干预措施。