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[卡马西平治疗手足搐搦综合征]

[Carbamazepine in the treatment of tetanic syndrome].

作者信息

Kukumberg P

机构信息

Neurologická klinika NsP akademika L. Dérera, LF KU, Bratislava.

出版信息

Cesk Neurol Neurochir. 1991 Mar;54(2):116-9.

PMID:2044172
Abstract

Neurogenic tetanic syndrome (synonyms: spasmophilia, chronic, larved, latent, hyperventilation tetany) causes problems due to its high incidence and torpid course. The aetiology is obscure. Sometimes mild disorders of the Ca and Mg metabolism are found. Carbamazepine was used in 288 patients (Biston Spofa: 3 months 600 mg/day). Subjective complaints improved by 58.7%, Chvostek's phenomenon reveded (44.3%). The typical EMG finding disappeared or improved in 73.0%. The psychotropic and antidepressive action of carbamazepine played a favourable role. No serious complications of treatment were observed. Carbamazepine inhibits effectively all manifestations of enhanced excitability of the nervous system. Its indication in the treatment of neurogenic tetanic syndrome is preferential.

摘要

神经源性强直综合征(同义词:痉挛素质、慢性、隐匿性、潜伏性、换气过度性手足搐搦)因其高发病率和隐匿病程而引发问题。病因不明。有时会发现钙和镁代谢的轻度紊乱。288例患者使用了卡马西平(比斯顿斯波法:3个月,600毫克/天)。主观症状改善了58.7%,Chvostek征消失(44.3%)。典型的肌电图表现消失或改善的比例为73.0%。卡马西平的精神otropic和抗抑郁作用发挥了有利作用。未观察到严重的治疗并发症。卡马西平有效抑制神经系统兴奋性增强的所有表现。其在神经源性强直综合征治疗中的适应证是优先的。

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