Suitsu N, Kita S, Okamoto S, Kimura S, Shiozaki Y
No To Shinkei. 1984 Aug;36(8):749-54.
The present authors observed and treated a siblings case of normocalcemic tetany, which is considered as belonging to Bartter's syndrome. As far as we know, there are a number of familial cases of tetany in literature, but none of them spreads over more than two generations, so that the tetany appears to be recessive in hereditary characters including our patients. Both of them presented tetanic seizures in the course of Bartter's syndrome and they were regarded as one of various manifestations of the syndrome. In other words, the Bartter's syndrome or the hypopotassemia should be one of the fundamental disorders for developing tetanic symptom. The tetanic symptoms became extinct during the treatment with spironolactone against hypopotassemia. Of the two patients, younger sister had shown an agitated depression developed on her childish and over-sensitive personality, but the depression was improved in parallel to the recovery from tetany and hypopotassemia. Therefore, it appears to be certain that the patients would have some premorbid deviation of personality traits, where symptomatic psychoses could be attributed, in the case of Bartter's syndrome. Generally speaking the psychic disorders, such as personality deviation and psychotic episode, seem to by very important symptoms in patient with Bartter's syndrome as well as in patient with hypocalcemia or hypoparathyroidism.
本文作者观察并治疗了一例手足搐搦症的同胞病例，该病例被认为属于巴特综合征。据我们所知，文献中有许多手足搐搦症的家族病例，但没有一个超过两代人患病，因此包括我们的患者在内，手足搐搦症在遗传特征上似乎是隐性的。他们两人在巴特综合征病程中均出现手足搐搦发作，且被视为该综合征的多种表现之一。换句话说，巴特综合征或低钾血症应该是引发手足搐搦症状的根本疾病之一。在用螺内酯治疗低钾血症期间，手足搐搦症状消失。在这两名患者中，妹妹表现出因幼稚且过度敏感的性格而产生的激动性抑郁，但随着手足搐搦症和低钾血症的恢复，抑郁症状也有所改善。因此，可以肯定的是，在巴特综合征的情况下，患者在发病前会有一些人格特质的偏差，而症状性精神病可能归因于此。一般来说，精神障碍，如人格偏差和精神病发作，似乎是巴特综合征患者以及低钙血症或甲状旁腺功能减退患者非常重要的症状。
