Department of Dermatology, Kosin University College of Medicine, Busan, South Korea.
J Dermatolog Treat. 2011 Aug;22(4):233-8. doi: 10.3109/09546631003686051. Epub 2010 May 6.
Melasma is difficult to treat and often recalcitrant to various treatments such as topical preparations and lasers.
To evaluate the efficacy and safety of the 1064-nm Q-switched Nd:YAG laser in Asian patients with melasma.
Twenty-three Korean patients (skin types III-V) with melasma were treated with the 1064-nm Q-switched Nd:YAG laser at 1-week intervals for 10 weeks. The melasma area and severity index (MASI) score, lightness of melasma, patient satisfaction score and side effects were assessed at baseline, 4, 7, and 10 weeks and 1, 2, and 3 months after the last treatment.
A decreased MASI score and increased lightness of melasma were statistically significant at 7 and 10 weeks. Follow-up data was statistically significant at 1, 2, and 3 months after the last treatment (p-value < 0.05). The patient satisfaction score was statistically significant at 4, 7, and 10 weeks. Follow-up data were statistically significant at 1, 2, and 3 months after the last treatment (p-value < 0.05). No significant side effects were noted.
The 1064-nm Q-switched Nd:YAG laser is a safe and effective modality for treating melasma in Asian patients.
黄褐斑治疗困难，常对各种治疗方法（如局部制剂和激光）产生抗药性。
评估 1064nm Q-开关 Nd：YAG 激光治疗亚洲黄褐斑患者的疗效和安全性。
23 例韩国黄褐斑患者（皮肤类型 III-V），每 1 周进行 1064nm Q-开关 Nd：YAG 激光治疗，共 10 周。在基线、4 周、7 周、10 周和最后一次治疗后 1、2、3 个月评估黄褐斑面积和严重程度指数（MASI）评分、黄褐斑亮度、患者满意度评分和不良反应。
7 周和 10 周时 MASI 评分降低和黄褐斑亮度增加具有统计学意义。末次治疗后 1、2、3 个月的随访数据具有统计学意义（p 值<0.05）。4 周、7 周和 10 周时患者满意度评分具有统计学意义。末次治疗后 1、2、3 个月的随访数据具有统计学意义（p 值<0.05）。未观察到明显的不良反应。
1064nm Q-开关 Nd：YAG 激光是治疗亚洲黄褐斑患者的一种安全有效的方法。
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