Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea.
Dermatol Surg. 2011 Aug;37(8):1133-40. doi: 10.1111/j.1524-4725.2011.02018.x. Epub 2011 May 17.
Melasma is a common acquired symmetrical hypermelanosis of sun-exposed areas of the skin. Although the classical Q-switched ruby laser (QSRL) has been used successfully for the removal of tattoos and for the treatment of cutaneous pigmented lesions, its efficacy for melasma remains controversial.
We used repeat low-dose fractional QSRL treatment for melasma and analyzed the clinical results.
Fifteen Korean women with melasma were enrolled. Each patient received six low-dose fractional QSRL treatments to the face at 2-week intervals. Two investigators independently evaluated Melasma Area and Severity Index (MASI) scores before each session and 4 and 16 weeks after the final session. The intensities of pigmentation and erythema were assessed by measuring skin reflectance using a tristimulus color analyzer.
Mean MASI score decreased from 15.1 ± 3.3 before treatment to 10.6 ± 3.9 16 weeks after the final treatment. The lightness of pigmentation (L-value) increased from 56.6 ± 3.5 before treatment to 59.9 ± 2.8 16 weeks after the final treatment.
Multiple treatment sessions of low-dose fractional QSRL may be an effective strategy for the treatment of dermal or mixed-type melasma.
黄褐斑是一种常见的获得性、对称性的皮肤色素沉着过度，发生于阳光暴露部位。虽然经典的 Q-开关红宝石激光（QSRL）已成功用于去除纹身和治疗皮肤色素性病变，但它在治疗黄褐斑方面的疗效仍存在争议。
我们使用重复低剂量的分数 QSRL 治疗黄褐斑，并分析其临床疗效。
共纳入 15 名韩国黄褐斑女性患者。每位患者在 2 周间隔内接受 6 次面部低剂量分数 QSRL 治疗。在每次治疗前和末次治疗后 4 周和 16 周，由两位研究者独立评估黄褐斑面积和严重程度指数（MASI）评分。使用三刺激颜色分析仪测量皮肤反射率来评估色素沉着和红斑的强度。
治疗前 MASI 评分均值为 15.1 ± 3.3，末次治疗后 16 周降至 10.6 ± 3.9。治疗前色素沉着的明度值（L 值）为 56.6 ± 3.5，末次治疗后 16 周增加至 59.9 ± 2.8。
多次低剂量分数 QSRL 治疗可能是治疗真皮或混合性黄褐斑的有效策略。
