MicroRNAs 作为基因组星系和疾病谜题中的新角色。
MicroRNAs as new players in the genomic galaxy and disease puzzles.
机构信息
Department of Morphology and Embryology, University of Ferrara, Ferrera, Italy.
出版信息
Clin Transl Sci. 2008 May;1(1):50-6. doi: 10.1111/j.1752-8062.2008.00028.x.
Abstract
Abstract MicroRNAs (miRNAs) are a large family of short, single-stranded, highly conserved noncoding RNAs involved in gene regulation that can regulate gene expression through sequence-specific base pairing with target messenger RNAs (mRNAs). miRNAs have been implicated in the development of a wide variety of cancers as well as heart disease and other diseases. This review describes the role of miRNAs in human disease, methodology for evaluating miRNA gene expression, and the potential role of miRNAs as therapeutic agents and targets for the treatment of disease.
摘要
摘要 微 RNA（miRNA）是一大类短的、单链、高度保守的非编码 RNA，参与基因调控，可通过与靶信使 RNA（mRNA）的序列特异性碱基配对来调节基因表达。miRNA 与多种癌症以及心脏病和其他疾病的发生有关。本文描述了 miRNA 在人类疾病中的作用、评估 miRNA 基因表达的方法学，以及 miRNA 作为治疗疾病的治疗剂和靶标的潜在作用。
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