结核的免疫调节：观察与启示。
Immunoregulation in TB: observations and implications.
机构信息
Boston University and Boston Medical Center, Boston, MA, USA.
出版信息
Clin Transl Sci. 2010 Feb;3(1):23-8. doi: 10.1111/j.1752-8062.2010.00180.x.
Abstract
Regulation of the immune response during active tuberculosis (TB) has been partly deciphered. In pulmonary TB there is transient systemic immunosuppression due to overexpression of transforming growth factor beta and interleukin-10. This is superimposed on a primary T-cell defect. Locally there is intense inflammation (lung, pleural fluid) with overexpression of immunosuppressive factors (bronchoalveolar lavage) and extensive apoptosis. These observations suggest that immune therapies should be aimed at neutralizing the negative regulatory factors rather than accentuating an already intense immune response. Also a partially effective vaccine carries the potential risk of exacerbating disease.
摘要
在活动性肺结核（TB）期间，免疫反应的调节已部分阐明。在肺结核中，由于转化生长因子β和白细胞介素-10 的过度表达，会出现短暂的全身免疫抑制。这是原发性 T 细胞缺陷的叠加。局部存在强烈的炎症（肺部、胸腔积液）和免疫抑制因子的过度表达（支气管肺泡灌洗）以及广泛的细胞凋亡。这些观察结果表明，免疫疗法应该旨在中和负调节因子，而不是增强已经强烈的免疫反应。此外，部分有效的疫苗具有加重疾病的潜在风险。
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