O'Garra Anne, Vieira Pedro L, Vieira Paulo, Goldfeld Anne E
Division of Immunoregulation, The National Institute for Medical Research, London, United Kingdom.
J Clin Invest. 2004 Nov;114(10):1372-8. doi: 10.1172/JCI23215.
Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also triggers anti-inflammatory circuits. Both inflammatory and anti-inflammatory reactions are normal components of the same immune response, which coordinately fight infections while preventing immune pathology. IL-10 is an important suppressive cytokine, produced by a large number of immune cells in addition to the antigen-driven IL-10-producing regulatory and the naturally occurring suppressor CD4+ T cells, which is a key player in anti-inflammatory immune responses. However, additional mechanisms have evolved to ensure that pathogen eradication is achieved with minimum damage to the host. Here we discuss those mechanisms that operate to regulate effector immune responses.
针对病原体的有效免疫反应有时会伴随着强烈的炎症反应。为了将对自身的损害降至最低，免疫系统的激活也会触发抗炎回路。炎症反应和抗炎反应都是同一免疫反应的正常组成部分，它们在对抗感染的同时协同预防免疫病理。白细胞介素-10（IL-10）是一种重要的抑制性细胞因子，除了抗原驱动产生IL-10的调节性细胞和天然存在的抑制性CD4+T细胞外，大量免疫细胞也能产生IL-10，它是抗炎免疫反应的关键参与者。然而，还进化出了其他机制来确保在对宿主造成最小损害的情况下实现病原体的根除。在此，我们讨论那些用于调节效应免疫反应的机制。
