成年雄性恒河猴（猕猴属）右耳廓的上皮样血管内皮瘤
Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta).
作者信息
Lombardini E D, Virmani R, Blanchard T W, Lafond J F, Ménard S, Doré M
机构信息
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington DC, USA.
出版信息
J Med Primatol. 2010 Oct;39(5):315-7. doi: 10.1111/j.1600-0684.2010.00411.x.
BACKGROUND
A 9-year-old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure.
RESULTS
Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells which infiltrated the myocardium and frequently exhibited intracytoplasmic luminae. Cells multifocally exhibited strong cytoplasmic immunoreactivity for Factor VIII-related protein (von Willebrand's factor).
CONCLUSIONS
The histological characteristics of this tumor are consistent with a diagnosis of epithelioid hemangioendothelioma, an intermediate-grade vasoformative neoplasm which has to our knowledge not previously been reported in the heart of a non-human species.
背景
一只9岁的雄性去势恒河猴在经历了长期的慢性肾衰竭后被安乐死。
结果
尸检发现右心耳内有一个增生性病变，由肿瘤性上皮样细胞组成，这些细胞浸润心肌，且常可见胞质内管腔。细胞多灶性地对VIII因子相关蛋白（血管性血友病因子）表现出强烈的胞质免疫反应性。
结论
该肿瘤的组织学特征符合上皮样血管内皮瘤的诊断，这是一种中等分化的血管形成性肿瘤，据我们所知，此前在非人类物种的心脏中尚未有过报道。
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