Struttura di Radiologia e Diagnostica per Immagini, Istituto Dermosifilopatico di Santa Maria e San Gallicano-IFO-Roma, Rome, Italy.
J Exp Clin Cancer Res. 2010 May 6;29(1):42. doi: 10.1186/1756-9966-29-42.
Calcifying epithelioma of Malherbe, or Pilomatricoma, is considered an uncommon cutaneous neoplasia, normally occurring in children as a solitary, firm, asymptomatic, hard, subcutaneous, slowly growing nodule on the face, neck, or proximal upper extremity. In literature, two Pilomatricoma ultrasound patterns are described: the totally calcified nodule and the hypoechoic nodule with internal calcific foci. High frequency ultrasound has not yet been applied for routine diagnosis of Pilomatricoma. The aim of the study was to retrospectively identify specific ultrasound features.
We retrieved 124 histologically Pilomatricoma cases: 28 patients with 32 lesions were preoperatively evaluated with ultrasound.
22/32 have shown a solid formation, hypoechoic, with a sharp outline. Of these 22, 10 lesions were completely calcifying and 12 partially calcified. In 3/32 lesions with uncertain diagnosis, ultrasounds showed a complex/mixed pattern with pseudo-fluid areas and microspots. 7/32 lesions with US different diagnosis included 3 complex lesions, 2 cystic lesions and 2 solid nodular lesions.
In addition to well-known ultrasound patterns (completely calcified and partially calcified) we identified three new, not yet described, patterns that constitute the 31% of the cases: complex, pseudocystic and pseudotumoral.
Malherbe 钙化上皮瘤，又称毛母质瘤，是一种罕见的皮肤肿瘤，通常发生于儿童，表现为单发、坚实、无症状、质硬、皮下、缓慢生长的面部、颈部或近端上肢结节。文献中描述了两种毛母质瘤的超声表现：完全钙化的结节和低回声的结节伴内部钙化灶。高频超声尚未用于毛母质瘤的常规诊断。本研究旨在回顾性识别其特定的超声特征。
我们回顾性分析了 124 例组织学证实的毛母质瘤病例：28 例患者 32 个病灶在术前进行了超声评估。
32 个病灶中，22 个表现为实性、低回声、边界清晰。其中 10 个完全钙化，12 个部分钙化。3 个病灶超声诊断不明确，表现为复杂/混合模式，存在假液区和微点。7 个超声诊断不同的病灶中，3 个为复杂病变，2 个为囊性病变，2 个为实性结节。
除了众所周知的超声模式（完全钙化和部分钙化）外，我们还发现了三种尚未描述的新的超声模式，占所有病例的 31%：复杂型、假囊型和假肿瘤型。
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