Kopecký I, Holec E
Ortopedická klinika 2. lékarské fakulty KU, Praha.
Acta Chir Orthop Traumatol Cech. 1994;61(4):227-9.
In the submitted paper the authors give an account on the use of Indomethacin in the prevention of paraarticular ossifications after implantation of a TEP of the hip joint, and on its effect of the development of these ossifications. This involves in particular inhibition of prostaglandin synthesis and partly also an antiphlogistic effect. The authors describe also their own observations regarding the effect of Indomethacin on the genesis and development of paraarticular ossifications. In the final evaluation they point out that Indomethacin does not reduce the incidence of paraarticular ossifications after implantation of TEP of the hip joint but contributes to the diminution of the final extent of ossification and thus has a positive effect on the final results of surgery. Key words: Indomethacin, paraarticular ossifications.
在提交的论文中，作者阐述了吲哚美辛在预防髋关节全聚乙烯置换（TEP）术后关节周围骨化方面的应用，以及其对这些骨化发展的影响。这尤其涉及对前列腺素合成的抑制，部分还涉及抗炎作用。作者还描述了他们自己关于吲哚美辛对关节周围骨化的发生和发展影响的观察结果。在最终评估中，他们指出吲哚美辛并不能降低髋关节TEP植入术后关节周围骨化的发生率，但有助于减小骨化的最终范围，从而对手术的最终结果产生积极影响。关键词：吲哚美辛，关节周围骨化
