更高磁场在傅里叶变换离子回旋共振质谱中的变革效应。
Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.
机构信息
Department of Chemistry and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA.
出版信息
J Am Soc Mass Spectrom. 2010 Jul;21(7):1218-22. doi: 10.1016/j.jasms.2010.03.033. Epub 2010 Mar 31.
Abstract
The relationship of magnetic field strength and Fourier transform ion cyclotron resonance mass spectrometry performance was tested using three instruments with the same design but different fields of 4.7, 7, and 9.4 tesla. We found that the theoretically predicted "transformative" effects of magnetic field are indeed observed experimentally. The most striking effects were that mass accuracy demonstrated approximately second to third order improvement with the magnetic field, depending upon the charge state of the analyte, and that peak splitting, which prohibited automated data analysis at 4.7 T, was not observed at 9.4 T.
摘要
我们使用三台设计相同但磁场强度分别为 4.7、7 和 9.4 特斯拉的仪器测试了磁场强度与傅立叶变换离子回旋共振质谱性能之间的关系。我们发现，理论上预测的磁场“变革性”效应确实在实验中得到了观察。最显著的效应是，磁场使质量精度提高了大约二到三阶，这取决于分析物的电荷状态，而在 4.7 T 时会阻止自动数据分析的峰分裂在 9.4 T 时则未观察到。
相似文献
1
Transformative effects of higher magnetic field in Fourier transform ion cyclotron resonance mass spectrometry.
J Am Soc Mass Spectrom. 2010 Jul;21(7):1218-22. doi: 10.1016/j.jasms.2010.03.033. Epub 2010 Mar 31.
2
A strategy for the determination of the elemental composition by fourier transform ion cyclotron resonance mass spectrometry based on isotopic peak ratios.
Anal Chem. 2010 Jul 1;82(13):5887-91. doi: 10.1021/ac902931x.
3
Fine structure in isotopic peak distributions measured using a dynamically harmonized Fourier transform ion cyclotron resonance cell at 7 T.
Anal Chem. 2012 Mar 6;84(5):2275-83. doi: 10.1021/ac202804f. Epub 2012 Feb 22.
4
Electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry at 11.5 tesla: instrument design and initial results.
J Am Soc Mass Spectrom. 1998 Jul;9(7):692-700. doi: 10.1016/s1044-0305(98)00037-3.
5
Fourier transform ion cyclotron resonance mass spectrometry at the true cyclotron frequency.
Mass Spectrom Rev. 2022 Mar;41(2):314-337. doi: 10.1002/mas.21681. Epub 2021 Jan 18.
6
Determination of ion magnetron radial distribution in Fourier transform ion cyclotron resonance mass spectrometry.
Rapid Commun Mass Spectrom. 1996;10(14):1855-9. doi: 10.1002/(SICI)1097-0231(199611)10:14<1855::AID-RCM764>3.0.CO;2-B.
7
Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
Annu Rev Phys Chem. 1999;50:517-36. doi: 10.1146/annurev.physchem.50.1.517.
8
Comparison of particle-in-cell simulations with experimentally observed frequency shifts between ions of the same mass-to-charge in Fourier transform ion cyclotron resonance mass spectrometry.
J Am Soc Mass Spectrom. 2010 Feb;21(2):203-8. doi: 10.1016/j.jasms.2009.10.001. Epub 2009 Oct 6.
9
Analysis of combinatorial libraries using electrospray Fourier transform ion cyclotron resonance mass spectrometry.
Rapid Commun Mass Spectrom. 1996;10(14):1860-4. doi: 10.1002/(SICI)1097-0231(199611)10:14<1860::AID-RCM770>3.0.CO;2-#.
10
The spontaneous loss of coherence catastrophe in Fourier transform ion cyclotron resonance mass spectrometry.
J Am Soc Mass Spectrom. 2009 Feb;20(2):247-56. doi: 10.1016/j.jasms.2008.09.028. Epub 2008 Oct 17.
引用本文的文献
1
Recent Developments and Application of Mass Spectrometry Imaging in N-Glycosylation Studies: An Overview.
Mass Spectrom (Tokyo). 2024;13(1):A0142. doi: 10.5702/massspectrometry.A0142. Epub 2024 Feb 27.
2
Applications and continued evolution of glycan imaging mass spectrometry.
Mass Spectrom Rev. 2023 Mar;42(2):674-705. doi: 10.1002/mas.21725. Epub 2021 Aug 15.
3
Fourier-transform ion cyclotron resonance mass spectrometry for characterizing proteoforms.
Mass Spectrom Rev. 2022 Mar;41(2):158-177. doi: 10.1002/mas.21653. Epub 2020 Sep 7.
4
21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer Greatly Expands Mass Spectrometry Toolbox.
J Am Soc Mass Spectrom. 2016 Dec;27(12):1929-1936. doi: 10.1007/s13361-016-1507-9. Epub 2016 Oct 12.
5
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.
Sci Rep. 2013 Oct 4;3:2859. doi: 10.1038/srep02859.
本文引用的文献
1
Trapping and detection of ions generated in a high magnetic field electrospray ionization fourier transform ion cyclotron resonance mass spectrometer.
J Am Soc Mass Spectrom. 1992 Sep;3(6):615-23. doi: 10.1016/1044-0305(92)85002-2.
2
Two-dimensional coulomb-induced frequency modulation in Fourier transform ion cyclotron resonance: A mechanism for line broadening at high mass and for large ion populations.
J Am Soc Mass Spectrom. 1993 Dec;4(12):909-16. doi: 10.1016/1044-0305(93)80016-R.
3
FT-ICR MS optimization for the analysis of intact proteins.
Int J Mass Spectrom. 2009 Oct 15;281(1-3):32-38. doi: 10.1016/j.ijms.2008.10.010.
4
High resolution mass spectrometry for rapid characterization of combinatorial peptide libraries.
J Comb Chem. 2010 Jan-Feb;12(1):65-8. doi: 10.1021/cc9001235.
5
Theory of peak coalescence in Fourier transform ion cyclotron resonance mass spectrometry.
Rapid Commun Mass Spectrom. 2009 Oct;23(19):3213-9. doi: 10.1002/rcm.4231.
6
Experimental Evidence for Space-Charge Effects between Ions of the Same Mass-to-Charge in Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry.
Int J Mass Spectrom. 2007 Sep 1;265(2-3):99-105. doi: 10.1016/j.ijms.2007.01.014.
7
A hierarchical algorithm for calculating the isotopic fine structures of molecules.
J Am Soc Mass Spectrom. 2008 Dec;19(12):1867-74. doi: 10.1016/j.jasms.2008.08.008. Epub 2008 Aug 15.
8
An electrically compensated trap designed to eighth order for FT-ICR mass spectrometry.
J Am Soc Mass Spectrom. 2008 Sep;19(9):1281-5. doi: 10.1016/j.jasms.2008.05.016. Epub 2008 Jul 2.
9
High-performance mass spectrometry: Fourier transform ion cyclotron resonance at 14.5 Tesla.
Anal Chem. 2008 Jun 1;80(11):3985-90. doi: 10.1021/ac800386h. Epub 2008 May 9.
10
Realistic modeling of ion cloud motion in a Fourier transform ion cyclotron resonance cell by use of a particle-in-cell approach.
Rapid Commun Mass Spectrom. 2007;21(22):3527-46. doi: 10.1002/rcm.3234.
Zotero 插件