Nawrocki J P, Wigger M, Watson C H, Hayes T W, Senko M W, Benner S A, Eyler J R
Department of Chemistry, University of Florida, Gainesville 32611-7200, USA.
Rapid Commun Mass Spectrom. 1996;10(14):1860-4. doi: 10.1002/(SICI)1097-0231(199611)10:14<1860::AID-RCM770>3.0.CO;2-#.
Electrospray ionization coupled with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry has been used to provide information about complete combinatorial libraries of small peptides containing 10(3)-10(4) components. The fidelity of attempted synthesis steps can be ascertained rapidly, and, when the extremely high resolution FTICR mass spectra are combined with appropriate computer simulation, both diversity and degeneracy of the libraries as synthesized can be assessed.
电喷雾电离与傅里叶变换离子回旋共振（FTICR）质谱联用，已被用于提供有关包含10³ - 10⁴个组分的小肽完整组合文库的信息。可以快速确定尝试合成步骤的保真度，并且，当将极高分辨率的FTICR质谱与适当的计算机模拟相结合时，就可以评估所合成文库的多样性和简并性。
