Ring H A, George M, Costa D C, Ell P J
Institute of Neurology, Queen Square, London, UK.
Eur J Nucl Med. 1991;18(2):133-41. doi: 10.1007/BF00950760.
Single photon emission tomography allows the imaging of dynamic brain functioning. The use of cerebral activating procedures within the scan protocol enables investigation of the mechanisms involved in specific brain functions in health and disease. Activation studies involve the comparison of at least two data sets describing brain activity generated in conditions that differ for the specific function in question. When designing an activation study, decisions regarding methodology include: the nature of the activation regime, the tracer-ligand utilized, the SPET instrument and the manner of subsequent data analysis. These issues are discussed in this review, both theoretically and with reference to published studies. Means of activating particular cerebral structures and functions are reviewed, as are the limitations of the techniques with respect to temporal and spatial resolution and the potentially confounding nature of preconceived ideas regarding the mechanisms of brain function.
单光子发射断层扫描可实现对大脑动态功能的成像。在扫描方案中使用大脑激活程序能够研究健康和疾病状态下特定脑功能所涉及的机制。激活研究涉及至少比较两组数据集，这些数据集描述了在针对所研究的特定功能而有所不同的条件下产生的大脑活动。在设计激活研究时，关于方法的决策包括：激活方案的性质、所使用的示踪剂-配体、单光子发射断层扫描仪以及后续数据分析的方式。本综述将从理论上并参考已发表的研究对这些问题进行讨论。文中将回顾激活特定脑结构和功能的方法，以及这些技术在时间和空间分辨率方面的局限性，还有关于脑功能机制的先入之见可能产生的混淆性质。
